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June 12, 2019

Comments

Yesterday the legislature in Albany voted to impose rent controls beyond those that already exist, which will inter alia have the effect of causing landlords to not undertake repairs in existing rental properties, and to further drive up the cost of unregulated rental units.

Earlier this year there was the scare-Amazon-away-from-Queens-and-kiss-off-billions-in-tax-revenue debacle in NYC.

Now we have this gem from another New York politician, who represents Brooklyn and - surprise! - Queens. I'll go out on a limb and venture that no pharmaceutical companies are headquartered in the 8th district, and that fewer of the constituents work for pharma than use drugs that are not FDA approved.

Keep it up. Investment money will find its way to where the returns are expected to be great. And if that's not in pharma, then there won't be new drugs.

Good grief. All these ill-conceived "solutions" seem to indicate that Congress makes decisions with less than half the facts and/or those lobbying for access to drugs today don't realize they are scorching the earth such that seeds of innovation will never result in a bounty of new drugs that are needed tomorrow (well, actually, that were needed yesterday).

The biosphere and life are ever-changing and the rate of change is increasing exponentially for many organisms. This means many drugs that work today may be ineffective in the near future. Drugs are not like other technologies such as a Boeing 747 that has a lifespan of about 30 years or the basic technology that allows us to fly. Point-in-fact: MRSA and also E. coli resistance to Ciprofloxacin. See below.

If Congress and others do not wise-up fast, we may soon find ourselves facing the bubonic plague like back in the Middle Ages.

"In the late 1940s and throughout the 1950s, S. aureus developed resistance to penicillin. Methicillin, a form of penicillin, was introduced [in 1959] to counter the increasing problem of penicillin-resistant S. aureus... 1961 ... was the so-called birth of MRSA. The first reported human case of MRSA in the United States came in 1968... MRSA is actually resistant to an entire class of penicillin-like antibiotics called beta-lactams. This class of antibiotics includes penicillin, amoxicillin, oxacillin, methicillin, and others" https://www.niaid.nih.gov/research/mrsa-antimicrobial-resistance-history

Ciprofloxacin was approved in October 1987. In 1999, about 5% E. coli isolates are resistant and by 2013 over 30% of isolates are resistant. See https://resistancemap.cddep.org/AntibioticResistance.php

"[N]ew antibiotic development has slowed to a standstill because of financial and regulatory disincentives." See
https://www.technologynetworks.com/immunology/articles/antimicrobial-resistance-the-rise-of-global-superbugs-309018

"Without effective antimicrobials for prevention and treatment of infections, medical procedures such as organ transplantation, cancer chemotherapy, diabetes management and major surgery (for example, caesarean sections or hip replacements) become very high risk." See
https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance

The bill number is H.R. 3199, and co-sponsors are Douglas Johnson (R-GA), Debbie Muscarsel-Powell (D-FL) and Ben Cline (R-VA).

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